UBC discovery could benefit 170 million people affected by hepatitis C

January 16, 2012 at 10:17 am Leave a comment

Researchers at the University of British Columbia have found a new way to block infection from the hepatitis C virus (HCV) in the liver that could lead to new therapies for those affected by this and other infectious diseases.

“HCV is constantly mutating, which makes it difficult to develop antiviral therapies that target the virus itself,” says François Jean, Associate Professor in the Department of Microbiology and Immunology and Scientific Director of the Facility for Infectious Disease and Epidemic Research (FINDER) at UBC. “So we decided to take a new approach.”

In a nutshell, previous studies have shown that lipid metabolism plays a crucial role in propogating the hepatitis C virus (HCV). As such, the UBC team hypothesized that antiviral agents that interfered with master regulators of lipid homeostasis may prove to be an effective target against HCV viral propogation. Their study demonstrates that subtilisin/kexin-isozyme-1 (SKI-1) – or site-1 protease (S1P). inhibition effectively blocks HCV from establishing infection in hepatoma cells. SKI-1 and S1P are involved in controlin the expression of key enzymes of cholesterol and fatty-acid biosynthesis which are important for infecting hepatoma cells.

The full press release can be read at EurekAlert! and the original research can be viewed in PLoS Pathogens.

Citation:
Olmstead AD, Knecht W, Lazarov I, Dixit SB, & Jean F. (2012) Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents. PLoS pathogens, 8(1). PMID: 22241994

Entry filed under: Biotechnology News and Info from Canadian Universities.

Giving sight to the blind Four Great Tips for Effective Protein Blotting

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Trackback this post  |  Subscribe to the comments via RSS Feed


biorad1

Bio-Rad Canada has sponsored the development of this site to advance the productivity of the Canadian Biotechnology sector and the fine people who work in it across the country.  We invite readers to contribute content: posters, tools, research and presentations, articles white papers, multimedia, music downloads and entertainment, conference announcements, videos. Please contact info@cbt20.ca for more information.

Bookmark and Share

Site developed by What If What Next(TM)

Follow us on Twitter


%d bloggers like this: