New function for an old gene leads Mount Sinai researchers to possible therapy for kidney disease
A new finding by Mount Sinai Hospital researchers has the potential to slow the progression of kidney disease, one of the most serious complications for patients with diabetes. Researchers have found a protein associated with kidney disease which potentially can be targeted with drugs in early stages of the disease to prevent end-stage kidney failure.
Published August 13, 2013 in Diabetes, the journal of the American Diabetes Association, the study was led by Dr. George Fantus, an endocrinologist at Mount Sinai Hospital’s Leadership Sinai Centre for Diabetes and a scientist at the Lunenfeld-Tanenbaum Research Institute. The research team discovered that a previously known protein named SRC (pronounced “sark”) is abnormally active in kidney cells that show early signs of this disease. The inappropriately active protein can lead to the build up of scar tissue, which diminishes the kidneys’ filtering ability to eliminate waste and excess fluid from the body.
Entry filed under: Biotechnology News and Info from Canadian Universities. Tags: Canadian Research, Diabetes.