Researchers led by Dr. Helen McNeill at the Lunenfeld-Tanenbaum Research Institute have revealed an exciting and unusual biochemical connection. Their discovery has implications for diseases linked to mitochondria, which are the primary sources of energy production within our cells.
Dr. McNeill’s team has an international reputation for their work in understanding how cells become organized into tissues and how growth is regulated during development. The group focuses on mutations in the fat (ft) gene. The protein product of this gene, called ‘Fat’, acts at the cell membrane to promote adhesion and communication between cells. Mutations in ft can cause cells to overgrow and become tumours. This occurs partially through the Hippo pathway, a pathway that is frequently activated in cancers such as liver, breast, ovarian and sarcomas.
Researchers at McGill University published in the journal Nature, turned to a living fish, called Polypterus, to help show what might have happened when fish first attempted to walk out of the water. Polypterus is an African fish that can breathe air, ‘walk’ on land, and looks much like those ancient fishes that evolved into tetrapods. The team of researchers raised juvenile Polypterus on land for nearly a year, with an aim to revealing how these ‘terrestrialized’ fish looked and moved differently.
I found a great post while surfing around called Scientists explain their processes with a little too much honesty [17 pictures]. The post is a compilation of some fantastic quotes from scientists letting you know what, politically incorrect, thought they are actually thinking when explaining their research data.
I really can’t do the post much justice without copying their material word for word, however I will give you my top three favorite quotes. I highly recommend that you check out the site and share your favorites with the rest of us. Here are mine:
- “We didn’t read half the papers we cite because they are behind a paywall!”
- “Experimental time points were chosen so that I didn’t have to come into the lab in the middle of the night or over the weekend”
- “Sample size was smaller than planned because I had been in grad school for 10 years & my supervisor wanted me to graduate!”
Don’t forget to checkout the original post here.