Posts tagged ‘Biotechnology in the Media’
Researchers at the Centre for Addiction and Mental Health have discovered two new genes linked to intellectual disability, according to two research studies published concurrently this month in the journals Human Genetics and Human Molecular Genetics.
“Both studies give clues to the different pathways involved in normal neurodevelopment,” says CAMH Senior Scientist Dr. John Vincent, who heads the MiND (Molecular Neuropsychiatry and Development) Laboratory in the Campbell Family Mental Health Research Institute at CAMH. “We are building up a body of knowledge that is informing us which kinds of genes are important to, and involved in, intellectual disabilities.”
In the first study, Dr. Vincent and his team used microarray genotyping to map the genes of a large Pakistani family which had intermarriage. Five members of the youngest generation were affected with mild to moderate intellectual disability. Dr. Vincent identified a truncation in the FBXO31 gene, which plays a role in the way that proteins are processed during development of neurons, particularly in the cerebellar cortex.
In the second study, using the same techniques, Dr. Vincent and his team analyzed the genes of two families with intermarriage, one Austrian and one Pakistani, and identified a disruption in the METTL23 gene linked to mild recessive intellectual disability. The METTL23 gene is involved in methylation—a process important to brain development and function.
About one per cent of children worldwide are affected by non-syndromic (i.e., the absence of any other clinical features) intellectual disability, a condition characterized by an impaired capacity to learn and process new or complex information, leading to decreased cognitive functioning and social adjustment. Although trauma, infection and external damage to the unborn fetus can lead to an intellectual disability, genetic defects are a principal cause.
These studies were part of an ongoing study of affected families in Pakistan, where the cultural tradition of large families and consanguineous (inter-) marriages among first cousins increases the likelihood of inherited intellectual disability in offspring.
“Although it is easier to find and track genes in consanguineous families, these genes are certainly not limited to them,” Dr. Vincent points out. A recent study estimated that 13 per cent of intellectual disability cases among individuals of European descent are caused when an individual inherits two recessive genes, meaning that results of this study are very relevant to populations such as Canada.
This type of autosomal recessive gene mutation haas traditionally been more difficult to trace, resulting in a paucity of research in this area. Parents of affected children show no symptoms, and the child must inherit one defective copy of the gene from each parent, so that only one in four offspring are likely to be affected. Smaller families, therefore, show a decreased frequency and are less amenable to this kind of study.
Dr. Vincent is currently engaged in a study that will screen Canadian populations of autism and intellectual disability for autosomal recessive gene mutations. Results will be available later this year.
A total of 42 genes linked to non-syndromic recessive forms of intellectual disability have now been identified; estimates suggest that up to 2,500 genes might be linked with intellectual disability, the majority being recessive.
Thanks to CAMH for contributing this story.
University of Alberta researchers have uncovered physical proof that animals existed 585 million years ago, 30 million years earlier than all previous established records show. The discovery was made U of A geologists Ernesto Pecoits and Natalie Aubet in Uruguay. They found fossilized tracks of a centimeter long, slug-like animal left behind 585 million years ago in a silty sediment.
How can technology transform the human body? Imagine this…
I created a swallowable perfume. … The fragrance comes out through the skin’s surface when you perspire.
Now watch the video.
Canadian native Marc Tessier-Lavigne will receive the prestigious Henry G. Friesen International Prize in Health Research which recognizes exceptional innovation by a visionary health leader of international stature. Tessier-Lavigne pioneered the identification of molecules that direct the formation of connections among nerve cells to establish neuronal circuits in the mammalian brain and spinal cord. The mechanisms he has identified are important for understanding how the human brain forms during normal development and in other processes, including nerve regeneration following spinal cord injury and neurodegeneration, as seen in Alzheimer’s disease. He has been a featured guest on The Charlie Rose Show and was named a “Leader for the 21st Century” by Time Magazine Canada.
Grad school. What have we done?
A University of British Columbia study has found traces of the bacteria listeria in ready-to-eat fish products sold in Metro Vancouver.
UBC food microbiologist Kevin Allen tested a total of 40 ready-to-eat fish samples prior to their best before date. Purchased from seven large chain stores and 10 small retailers in Metro Vancouver, these products included lox, smoked tuna, candied salmon and fish jerky.
The findings – published in a recent issue of the journal Food Microbiology – show that listeria was present in 20 per cent of the ready-to-eat fish products. Of these, five per cent had the more virulent variety of listeria monocytogenes.